Extended dwell intravenous (IV) therapy with ultrasound guidance is a cost-effective alternative to Peripherally Inserted Central Catheters (PICC) and Midline catheters for certain medical cases. It involves leaving an IV catheter in place for an extended period, typically ranging from several days to several weeks, utilizing ultrasound technology for precise placement and monitoring. The cost-effectiveness is realized through reduced expenses related to training, maintenance, and fewer replacements. Moreover, it minimizes complications, conserves healthcare resources, reduces patient discomfort, and decreases the risk of catheter-related infections, making it a compelling choice in the appropriate medical contexts.